The third Week of NFL 2010 Preseason features the Chargers vs the Saints and a San Francisco vs Oakland “battle of California” game. Odds are this will be a good week of football as regular season begins in no time.
| Thu, Aug 26 | Stadium | Time (ET) | Network |
| Saint Louis Rams @ New England Patriots | Gillette Stadium | 7:30 PM | |
| Indianapolis Colts @ Green Bay Packers | Lambeau Field | 8:00 PM | ESPN |
| Fri, Aug 27 | Stadium | Time (ET) | Network |
| Atlanta Falcons @ Miami Dolphins | Sun Life Stadium | 7:00 PM | |
| Washington Redskins @ New York Jets | New Meadowlands Stadium | 7:00 PM | |
| San Diego Chargers @ New Orleans Saints | Superdome | 8:00 PM | CBS |
| Philadelphia Eagles @ Kansas City Chiefs | Arrowhead Stadium | 8:00 PM | |
| Sat, Aug 28 | Stadium | Time (ET) | Network |
| Cleveland Browns @ Detroit Lions | Ford Field | 5:00 PM | |
| Cincinnati Bengals @ Buffalo Bills | Ralph Wilson Stadium | 6:30 PM | |
| Jacksonville Jaguars @ Tampa Bay Buccaneers | Raymond James Stadium | 7:30 PM | |
| NY Giants @ Baltimore Ravens | M&T Bank Stadium | 7:30 PM | |
| Dallas Cowboys @ Houston Texans | Reliant Stadium | 8:00 PM | CBS |
| Seattle Seahawks @ Minnesota Vikings | Mall of America Field | 8:00 PM | |
| Tennessee Titans @ Carolina Panthers | Bank of America Stadium | 8:00 PM | |
| Arizona Cardinals @ Chicago Bears | Soldier Field | 8:30 PM | |
| San Francisco 49ers @ Oakland Raiders | Oakland Coliseum | 9:00 PM | |
| Sun, Aug 29 | Stadium | Time (ET) | Network |
| Pittsburgh Steelers @ Denver Broncos | Invesco Field at Mile High | 8:00 PM | FOX |